Africa Leads Way With HIV/AIDS Shot: 3 Nations Begin 99.9% Prevention Rollout for Millions

South Africa, Eswatini, and Zambia were to begin on Monday administering a groundbreaking new HIV-prevention injection in the drug’s first public rollouts in Africa, which has the world’s highest HIV/AIDS burden.

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Lenacapavir, taken twice a year, has been shown to reduce the risk of HIV transmission by more than 99.9 percent, making it functionally akin to a powerful vaccine.

In South Africa, where one in five adults lives with HIV, a Wits University research unit oversaw the rollout as part of an initiative funded by Unitaid, the United Nations health agency.

“The first individuals have begun using lenacapavir for HIV prevention in South Africa … making it among the first real-world use of the 6-monthly injectable in low-and middle-income countries,” Unitaid said in a statement.

It did not specify how many people received the first doses of the drug, which cost $28,000 per person a year in the United States. A broader national rollout is expected next year.

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Neighbouring Zambia and Eswatini received 1,000 doses last month as part of a US programme and were expected to launch the drug at World AIDS Day ceremonies on Monday.

Under the programme, manufacturer Gilead Sciences has agreed to provide lenacapavir at no profit to two million people in countries with a high HIV burden over three years.

Critics say this is far below the actual requirement and that the market price is out of reach for most people.

Eastern and southern Africa account for about 52 percent of the 40.8 million people living with HIV worldwide, according to 2024 UNAIDS data.

Generic versions of lenacapavir are expected to be available from 2027 at around $40 per year in more than 100 countries, through agreements by Unitaid and the Gates Foundation with Indian pharmaceutical companies.

Pre-exposure prophylaxis, or PrEP, has been used for over a decade to prevent HIV, but its reliance on a daily pill has limited its impact on global infections.

About World AIDS Day

World AIDS Day, designated on 1 December every year since 1988, is an international day dedicated to raising awareness of the AIDS pandemic caused by the spread of HIV infection and mourning those who have died of the disease. The acquired immunodeficiency syndrome (AIDS) is a life-threatening condition caused by the human immunodeficiency virus (HIV). The HIV virus attacks the immune system of the patient and reduces its resistance to other diseases. Government and health officials, non-governmental organizations, and individuals around the world observe the day, often with education on AIDS prevention and control.

World AIDS Day is one of the eleven official global public health campaigns marked by the World Health Organization (WHO), along with World Health Day, World Blood Donor Day, World Immunization Week, World Tuberculosis Day, World No Tobacco Day, World Malaria Day, World Hepatitis Day, World Antimicrobial Awareness Week, World Patient Safety Day and World Chagas Disease Day.